I haven't laughed so much while reading a book since my latest Christopher Moore fix. What a surprise to have this be his debut novel and from a doctor, no less. I enjoyed all of the footnotes and the medical references, always into weird medical information. Even though the main character has mainly unlikeable characteristics, I couldn't help but cheer as he fought, shot and killed his way through his mafioso "family". I also like the twist with his grandparents' true heritage. I enjoyed the way this book started in one place and ended up in a totally new situation by the end (from doctor to mafia hitman to protected witness). Honestly, if I had read that it was about the mafia, I probably wouldn't have picked it up, but I enjoyed this novel so much, that when I woke up for my midnight potty time, I actually stayed up and finished this book!